Title looms for City, Real slump
Man City were 4-0 winners over Aston Villa at the Etihad, while Madrid were held to a 1-1 draw in a must win match at Real Valladolid.
Edin Dzeko bagged a brace for the Citizens, Stefan Jovetic and Yaya Toure were also on target.
Manuel Pellegini's men are now two points clear at the summit.
A draw in Sundays encounter against Westham would be enough to secure their second title in three seasons.
Madrid's title hopes are shattered after the draw.
Carlo Ancelotti's men are third on the log on 84 points with two games left in the season.
Los Blancos are a point behind their Arch-rivals Barcelona and four adrift of log leaders Atletico Madrid.
Real and Atletico will meet in the Uefa Champions League final in Lisbon on May 24.
(File photo:Gallo Images)